Infectious diseases have become a growing health problem worldwide. Thus, the search for novel non-toxic and effective approaches with immune system- enhancing effects, so it can resist and fight these infections is still sought after. It has been firmly established that both nutrition and the availability of specific micronutrients are important for achieving optimum immunity. In this study, we investigated the effects of natural compounds in enhancing the cellular response of immune cells to various challenges. The results showed that some vitamins, minerals, and plant extracts had significant enhancing effects on specific immune responses tested in this study. However, a combination of these natural compounds had superior efficacy compared to any of the individual substances in increasing phagocytic activity against specific bacteria and yeast. This micronutrient combination also increased the efficacy of NK cells in eliminating abnormal (cancer) cells as well as inhibiting the release of pro- inflammatory IL-6 by RAW macrophages. This composition of nutrients offers significant pleiotropic benefits in supporting the immune system function.